Osmosis Jones

Chris Rock

Osmosis Jones (voice)

Laurence Fishburne

Thrax (voice)

David Hyde Pierce

Drix (voice)

Brandy Norwood

Leah (voice)

Elena Franklin

Shane Detorre

Bill Murray

Frank Detorre

William Shatner

Mayor Phlegmming (voice)

Ron Howard

Tom Colonic (voice)

Kid Rock

Kidney Rock (voice)

Molly Shannon

Mrs. Boyd

Chris Elliott

Bob

Jonathan Adams

Officer Tom (voice)

Carlos Alazraqui

Spanish Germ (voice)

Keith Anthony

Additional Character Voices (voice)

Eddie Barth

Conductor (voice)

Sally Brooks

Additional Character Voices (voice)

Rodger Bumpass

Joe Cramp / Announcer for Nerve News Network (voice)

Michael Carven

Additional Character Voices (voice)

Zak Penn

Producer

Peter Farrelly

Director, Producer

Stephen Schaffer

Editor

Bobby Farrelly

Director, Producer

Bradley Thomas

Producer

Mark Irwin

Director of Photography

Lois Freeman-Fox

Editor

Randy Edelman

Original Music Composer

Sam Seig

Editor

Dennis Edwards

Producer

Marc Hyman

Writer